While beings like The Anti-Monitor are popular right now, thanks to the upcoming Arrowverse crossover event Crisis on Infinite Earths , there is one foe who has withstood the test of time and has become a monstrous villain: Darkseid. In the end, it could be a testimony to his tenacity. Then again, it may be that he doesn't learn his lessons. Hence, the reason they're a few more heroes everyone forgets defeated Darkseid. So much so that DC and Marvel decided to team the two groups together in a giant one-shot. In the real world, the book was written by Chris Claremont and illustrated by Walt Simonson. In the blended comic universe, the teams had to defeat not only Darkseid by Dark Phoenix.
Armed with the Anti-Life Equation, the Dark Lord of Apokolips and father of Orion seeks to control all sentient life throughout the universe…and beyond. In the known DC Multiverse, one name stands above all others when it comes to supreme villainy—Darkseid. To this end, Darkseid employs the vast power at his disposal to seek out the Anti-Life Equation, a mysterious formula that would allow him to remove all free will from every sentient life-form in the known universe.
Darkseid is the ruler of Apokolips and Darkseid's Elite and was a major player in the cosmic war that was the Final Crisis. Unto the hell that is Apokolips came Darkseid, pure hatred personified, a merciless tyrant who demanded unwavering devotion and abject fear from all his subjects. A being of unparalleled strength, Darkseid nevertheless preferred not to sully his gloves with combat unless provoked to action. His eyes emitted the formidable Omega Sanction , ray beams that could disintegrate, teleport, or resurrect depending on the dread lord's wishes. His sole mission in life was to find and gain control over the Anti-Life Equation which would give him the means to usurp all free will in the sentient universe.
In another universe, the Old Gods were immortal beings who relied on the prayers of mortals to remain in power, but nevertheless cared nothing about them. Soon the rebellious Uxas began putting lies and corruption in the minds of these Gods which sparked a war between them. As the gods began to die, Uxas began stealing the Gods' power for himself. Eventually, when his father Yuga Khan came to strike down both him and his brother Izaya for their insolence against the Old Gods, he used the Anti-Life to revive the Olds Gods Uxas murdered, but was ultimately slain by his own son  who took the fallen Gods' power to become the New God Darkseid. Izaya, too, received power from the Old Gods and confronted him, claiming they were New Gods who should unite to bring forth a new age, but Darkseid only felt disdain and destroyed their world, with only him and Izaya remaining. As eons passed, Darkseid created the hellpit of Apokolips and has remained as its sole ruler, with the only force capable of opposing him being his brother Highfather and his forces of New Genesis. Darkseid conceived many sons; one, Kalibak , became a brutal warrior of Apokolips while another, Orion , was traded for Highfather's own Scot in a promise of peace between both planets. Some time ago Darkseid came across Myrina , an Amazon from a parallel universe and conceived another child with her, a daughter named Grail ,  who unbeknownst to him was being raised to destroy him. One day, his daughter of an unknown mother, a mischief-maker named Kaiyo , defied Darkseid's authority by laughing at his law, prompting him to pursue her across universes she would escape through.